Open Close
Reference
Citation
Berry, J.A., Cervantes-Sandoval, I., Chakraborty, M., Davis, R.L. (2015). Sleep Facilitates Memory by Blocking Dopamine Neuron-Mediated Forgetting.  Cell 161(7): 1656--1667.
FlyBase ID
FBrf0228725
Publication Type
Research paper
Abstract

Early studies from psychology suggest that sleep facilitates memory retention by stopping ongoing retroactive interference caused by mental activity or external sensory stimuli. Neuroscience research with animal models, on the other hand, suggests that sleep facilitates retention by enhancing memory consolidation. Recently, in Drosophila, the ongoing activity of specific dopamine neurons was shown to regulate the forgetting of olfactory memories. Here, we show this ongoing dopaminergic activity is modulated with behavioral state, increasing robustly with locomotor activity and decreasing with rest. Increasing sleep-drive, with either the sleep-promoting agent Gaboxadol or by genetic stimulation of the neural circuit for sleep, decreases ongoing dopaminergic activity, while enhancing memory retention. Conversely, increasing arousal stimulates ongoing dopaminergic activity and accelerates dopaminergic-based forgetting. Therefore, forgetting is regulated by the behavioral state modulation of dopaminergic-based plasticity. Our findings integrate psychological and neuroscience research on sleep and forgetting.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC4671826 (PMC) (EuropePMC)
Related Publication(s)
Note

Flies Sleep on It, or Fuhgeddaboudit!
Rihel and Bendor, 2015, Cell 161(7): 1498--1500 [FBrf0229476]

Sleep: Don't forget.
Whalley, 2015, Nat. Rev. Neurosci. 16(8): 442--443 [FBrf0229744]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference