Open Close
Reference
Citation
Gilboa, L. (2015). Organizing stem cell units in the Drosophila ovary.  Curr. Opin. Genet. Dev. 32(): 31--36.
FlyBase ID
FBrf0228735
Publication Type
Review
Abstract

Organogenesis utilizes processes fundamental to development: cell proliferation, cell differentiation and morphogenesis. Each of these processes is complex in itself; the challenge of studying organogenesis is to determine how all of them integrate to shape organs with recurring precision. This review focuses on the emerging understanding of how synchronized proliferation and differentiation of both somatic and germ cell lineages form 16-20 germ line stem cell (GSC) units in the ovary of Drosophila melanogaster. Recent work demonstrates that the Insulin, ecdysone, Epidermal Growth Factor, Decapentaplegic and Activin signaling pathways are used reiteratively for proliferation and differentiation in both somatic and germ cell lineages. This linkage underlies ovarian coordinated development and provides opportunity for correction mechanisms for stem cell unit numbers.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Opin. Genet. Dev.
    Title
    Current Opinion in Genetics and Development
    Publication Year
    1991-
    ISBN/ISSN
    0959-437X
    Data From Reference
    Genes (8)