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Citation
Mills, A.A. (2010). Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins.  Nat. Rev. Cancer 10(10): 669--682.
FlyBase ID
FBrf0228972
Publication Type
Review
Abstract
The discovery that cancer can be governed above and beyond the level of our DNA presents a new era for designing therapies that reverse the epigenetic state of a tumour cell. Understanding how altered chromatin dynamics leads to malignancy is essential for controlling tumour cells while sparing normal cells. Polycomb and trithorax group proteins are evolutionarily conserved and maintain chromatin in the 'off' or 'on' states, thereby preventing or promoting gene expression, respectively. Recent work highlights the dynamic interplay between these opposing classes of proteins, providing new avenues for understanding how these epigenetic regulators function in tumorigenesis.
PubMed ID
PubMed Central ID
PMC4068012 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Rev. Cancer
    Title
    Nature Reviews. Cancer
    Publication Year
    2001-
    ISBN/ISSN
    1474-175X 1474-1768
    Data From Reference