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Schuettengruber, B., Martinez, A.M., Iovino, N., Cavalli, G. (2011). Trithorax group proteins: switching genes on and keeping them active.  Nat. Rev. Mol. Cell Biol. 12(12): 799--814.
FlyBase ID
FBrf0228973
Publication Type
Review
Abstract

Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein MLL in leukaemia. However, in terms of molecular analysis, they have lived in the shadow of their more famous counterparts, the PcG proteins. Recent advances have improved our understanding of TrxG protein function and demonstrated that the heterogeneous group of TrxG proteins is of critical importance in the epigenetic regulation of the cell cycle, senescence, DNA damage and stem cell biology.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Rev. Mol. Cell Biol.
    Title
    Nature Reviews. Molecular Cell Biology
    Publication Year
    2000-
    ISBN/ISSN
    1471-0072
    Data From Reference