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Citation
Ng, F.S., Jackson, F.R. (2015). The ROP vesicle release factor is required in adult Drosophila glia for normal circadian behavior.  Front. Cell. Neurosci. 9(): 256.
FlyBase ID
FBrf0229000
Publication Type
Research paper
Abstract

We previously showed that endocytosis and/or vesicle recycling mechanisms are essential in adult Drosophila glial cells for the neuronal control of circadian locomotor activity. In this study, our goal was to identify specific glial vesicle trafficking, recycling, or release factors that are required for rhythmic behavior. From a glia-specific, RNAi-based genetic screen, we identified eight glial factors that are required for normally robust circadian rhythms in either a light-dark cycle or in constant dark conditions. In particular, we show that conditional knockdown of the ROP vesicle release factor in adult glial cells results in arrhythmic behavior. Immunostaining for ROP reveals reduced protein in glial cell processes and an accumulation of the Par Domain Protein 1ε (PDP1ε) clock output protein in the small lateral clock neurons. These results suggest that glia modulate rhythmic circadian behavior by secretion of factors that act on clock neurons to regulate a clock output factor.

PubMed ID
PubMed Central ID
PMC4490253 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Front. Cell. Neurosci.
    Title
    Frontiers in cellular neuroscience
    ISBN/ISSN
    1662-5102
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