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Stratoulias, V., Heino, T.I. (2015). Analysis of the conserved neurotrophic factor MANF in the Drosophila adult brain.  Gene Expr. Patterns 18(1-2): 8--15.
FlyBase ID
FBrf0229112
Publication Type
Research paper
Abstract

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an evolutionarily conserved neurotrophic factor that supports and protects dopaminergic neurons. The Drosophila MANF (DmMANF) null mutant animals die during early development, and DmMANF is required for the maintenance of dopamine positive neurites. The aim of this study was to investigate the role of DmMANF during later developmental stages. Here we report that DmMANF expression in the adult brain is much wider than in the embryonic and larval stages. It is expressed in both glia and neurons including dopaminergic neurons. Clonal analysis showed that DmMANF is not required cell-autonomously for the differentiation of either glia or dopaminergic neurons. In addition, DmMANF overexpression resulted in no apparent abnormal dopaminergic phenotype while DmMANF silencing in glia resulted in prolonged larval stage.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Gene Expr. Patterns
    Title
    Gene expression patterns : GEP
    Publication Year
    2002-
    ISBN/ISSN
    1567-133X 1872-7298
    Data From Reference