Open Close
Reference
Citation
Chang, L., Kreko-Pierce, T., Eaton, B.A. (2015). The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth.  Biol. Open 4(8): 947--953.
FlyBase ID
FBrf0229264
Publication Type
Research paper
Abstract

The generation of neuronal morphology requires transport vesicles originating from the Golgi apparatus (GA) to deliver specialized components to the axon and dendrites. Drosophila Arfaptin is a membrane-binding protein localized to the GA that is required for the growth of the presynaptic nerve terminal. Here we provide biochemical, cellular and genetic evidence that the small GTPase Arl1 and the guanine-nucleotide exchange factor (GEF) Gartenzwerg are required for Arfaptin function at the Golgi during synapse growth. Our data define a new signaling pathway composed of Arfaptin, Arl1, and Garz, required for the generation of normal synapse morphology.

PubMed ID
PubMed Central ID
PMC4542281 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biol. Open
    Title
    Biology open
    ISBN/ISSN
    2046-6390
    Data From Reference
    Aberrations (1)
    Alleles (14)
    Genes (17)
    Physical Interactions (2)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (4)
    Experimental Tools (3)
    Transgenic Constructs (5)