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Citation
Volkenhoff, A., Weiler, A., Letzel, M., Stehling, M., Klämbt, C., Schirmeier, S. (2015). Glial Glycolysis Is Essential for Neuronal Survival in Drosophila.  Cell Metab. 22(3): 437--447.
FlyBase ID
FBrf0229477
Publication Type
Research paper
Abstract

Neuronal information processing requires a large amount of energy, indicating that sugars and other metabolites must be efficiently delivered. However, reliable neuronal function also depends on the maintenance of a constant microenvironment in the brain. Therefore, neurons are efficiently separated from circulation by the blood-brain barrier, and their long axons are insulated by glial processes. At the example of the Drosophila brain, we addressed how sugar is shuttled across the barrier to nurture neurons. We show that glial cells of the blood-brain barrier specifically take up sugars and that their metabolism relies on glycolysis, which, surprisingly, is dispensable in neurons. Glial cells secrete alanine and lactate to fuel neuronal mitochondria, and lack of glial glycolysis specifically in the adult brain causes neurodegeneration. Our work implies that a global metabolic compartmentalization and coupling of neurons and glial cells is a conserved, fundamental feature of bilaterian nervous systems independent of their size.

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Obtained with permission from Cell Press.
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PubMed Central ID
Related Publication(s)
Personal communication to FlyBase

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Note

Brain Energy Metabolism: Conserved Functions of Glycolytic Glial Cells.
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Metab.
    Title
    Cell Metabolism
    Publication Year
    2005-
    ISBN/ISSN
    1550-4131
    Data From Reference
    Aberrations (1)
    Alleles (63)
    Gene Groups (1)
    Genes (42)
    Polypeptides (3)
    Natural transposons (1)
    Insertions (5)
    Experimental Tools (2)
    Transgenic Constructs (18)