Open Close
Reference
Citation
Denton, D., Xu, T., Kumar, S. (2015). Autophagy as a pro-death pathway.  Immunol. Cell Biol. 93(1): 35--42.
FlyBase ID
FBrf0229499
Publication Type
Review
Abstract

The evolutionarily conserved catabolic process of autophagy involves the degradation of cytoplasmic components through lysosomal enzymes. Basal levels of autophagy maintain cellular homeostasis and under stress conditions high levels of autophagy are induced. It is often under such stress conditions that high levels of autophagy and cell death have been observed, leading to the idea that autophagy may act as an executioner of cell death. However the notion of autophagy as a cell death mechanism has been controversial and remains mechanistically undefined. There is now growing evidence that in specific contexts autophagy can indeed facilitate cell death. The pro-death role of autophagy is however complicated due to the extensive cross-talk between different signalling pathways. This review summarises the examples of where autophagy acts as a means of cell death and discusses the association of autophagy with the different cell death pathways.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Immunol. Cell Biol.
    Title
    Immunology and Cell Biology
    Publication Year
    1987-
    ISBN/ISSN
    0818-9641
    Data From Reference