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Reference
Citation
Yan, D., Perrimon, N. (2015). spenito is required for sex determination in Drosophila melanogaster.  Proc. Natl. Acad. Sci. U.S.A. 112(37): 11606--11611.
FlyBase ID
FBrf0229644
Publication Type
Research paper
Abstract
Sex-lethal (Sxl) encodes the master regulator of the sex determination pathway in Drosophila and acts by controlling sex identity in both soma and germ line. In females Sxl maintains its own expression by controlling the alternative splicing of its own mRNA. Here, we identify a novel sex determination gene, spenito (nito) that encodes a SPEN family protein. Loss of nito activity results in stem cell tumors in the female germ line as well as female-to-male somatic transformations. We show that Nito is a ubiquitous nuclear protein that controls the alternative splicing of the Sxl mRNA by interacting with Sxl protein and pre-mRNA, suggesting that it is directly involved in Sxl auto-regulation. Given that SPEN family proteins are frequently mutated in cancers, our results suggest that these factors might be implicated in tumorigenesis through splicing regulation.
PubMed ID
PubMed Central ID
PMC4577178 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase
Location data for @nito[1]@ excision allele.
Yan, 2016.1.15, Location data for @nito[1]@ excision allele. [FBrf0230723]
Associated Information
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Aberrations (1)
    Alleles (323)
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    Genes (255)
    Physical Interactions (4)
    Cell Lines (1)
    Insertions (4)
    Transgenic Constructs (319)
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