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Citation
Fu, J., Hagan, I.M., Glover, D.M. (2015). The centrosome and its duplication cycle.  Cold Spring Harbor Perspect. Biol. 7(2): a015800.
FlyBase ID
FBrf0229776
Publication Type
Review
Abstract

The centrosome was discovered in the late 19th century when mitosis was first described. Long recognized as a key organelle of the spindle pole, its core component, the centriole, was realized more than 50 or so years later also to comprise the basal body of the cilium. Here, we chart the more recent acquisition of a molecular understanding of centrosome structure and function. The strategies for gaining such knowledge were quickly developed in the yeasts to decipher the structure and function of their distinctive spindle pole bodies. Only within the past decade have studies with model eukaryotes and cultured cells brought a similar degree of sophistication to our understanding of the centrosome duplication cycle and the multiple roles of this organelle and its component parts in cell division and signaling. Now as we begin to understand these functions in the context of development, the way is being opened up for studies of the roles of centrosomes in human disease.

PubMed ID
PubMed Central ID
PMC4315929 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cold Spring Harbor Perspect. Biol.
    Title
    Cold Spring Harbor perspectives in biology
    ISBN/ISSN
    1943-0264
    Data From Reference
    Genes (14)