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Citation
Homem, C.C., Repic, M., Knoblich, J.A. (2015). Proliferation control in neural stem and progenitor cells.  Nat. Rev. Neurosci. 16(11): 647--659.
FlyBase ID
FBrf0229912
Publication Type
Review
Abstract

Neural circuit function can be drastically affected by variations in the number of cells that are produced during development or by a reduction in adult cell number owing to disease. For this reason, unique cell cycle and cell growth control mechanisms operate in the developing and adult brain. In Drosophila melanogaster and in mammalian neural stem and progenitor cells, these mechanisms are intricately coordinated with the developmental age and the nutritional, metabolic and hormonal state of the animal. Defects in neural stem cell proliferation that result in the generation of incorrect cell numbers or defects in neural stem cell differentiation can cause microcephaly or megalencephaly.

PubMed ID
PubMed Central ID
PMC4667397 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Rev. Neurosci.
    Title
    Nature Reviews. Neuroscience
    Publication Year
    2000-
    ISBN/ISSN
    1471-0048 1471-003X
    Data From Reference