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Citation
Nässel, D.R., Liu, Y., Luo, J. (2015). Insulin/IGF signaling and its regulation in Drosophila.  Gen. Comp. Endocrinol. 221(): 255--266.
FlyBase ID
FBrf0230017
Publication Type
Review
Abstract

Taking advantage of Drosophila as a genetically tractable experimental animal much progress has been made in our understanding of how the insulin/IGF signaling (IIS) pathway regulates development, growth, metabolism, stress responses and lifespan. The role of IIS in regulation of neuronal activity and behavior has also become apparent from experiments in Drosophila. This review briefly summarizes these functional roles of IIS, and also how the insulin producing cells (IPCs) are regulated in the fly. Furthermore, we discuss functional aspects of the spatio-temporal production of eight different insulin-like peptides (DILP1-8) that are thought to act on one known receptor (dInR) in Drosophila.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Gen. Comp. Endocrinol.
    Title
    General and Comparative Endocrinology
    Publication Year
    1961-
    ISBN/ISSN
    0016-6480
    Data From Reference