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Citation
Isabella, A.J., Horne-Badovinac, S. (2015). Building from the Ground up: Basement Membranes in Drosophila Development.  Curr. Top. Membr. 76(): 305--336.
FlyBase ID
FBrf0230242
Publication Type
Review
Abstract
Basement membranes (BMs) are sheetlike extracellular matrices found at the basal surfaces of epithelial tissues. The structural and functional diversity of these matrices within the body endows them with the ability to affect multiple aspects of cell behavior and communication; for this reason, BMs are integral to many developmental processes. The power of Drosophila genetics, as applied to the BM, has yielded substantial insight into how these matrices influence development. Here, we explore three facets of BM biology to which Drosophila research has made particularly important contributions. First, we discuss how newly synthesized BM proteins are secreted to and assembled exclusively on basal epithelial surfaces. Next, we examine how regulation of the structural properties of the BM mechanically supports and guides tissue morphogenesis. Finally, we explore how BMs influence development through the modulation of several major signaling pathways.
PubMed ID
PubMed Central ID
PMC4772872 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Top. Membr.
    Title
    Current Topics in Membranes
    Publication Year
    1991-
    ISBN/ISSN
    1063-5823
    Data From Reference
    Gene Groups (2)
    Genes (6)