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Citation
Liu, D., Shaukat, Z., Saint, R.B., Gregory, S.L. (2015). Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll.  Oncotarget 6(36): 38552--38565.
FlyBase ID
FBrf0230345
Publication Type
Research paper
Abstract
Chromosomal instability (CIN) is a hallmark of cancer and has been implicated in cancer initiation, progression and the development of resistance to traditional cancer therapy. Here we identify a new property of CIN cells, showing that inducing CIN in proliferating Drosophila larval tissue leads to the activation of innate immune signalling in CIN cells. Manipulation of this immune pathway strongly affects the survival of CIN cells, primarily via JNK, which responds to both Toll and TNF╬▒/Eiger. This pathway also activates Mmp1, which recruits hemocytes to the CIN tissue to provide local amplification of the immune response that is needed for effective elimination of CIN cells.
PubMed ID
PubMed Central ID
PMC4770720 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Oncotarget
    Title
    Oncotarget
    ISBN/ISSN
    1949-2553
    Data From Reference