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Citation
Carrillo, R.A., Özkan, E., Menon, K.P., Nagarkar-Jaiswal, S., Lee, P.T., Jeon, M., Birnbaum, M.E., Bellen, H.J., Garcia, K.C., Zinn, K. (2015). Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins.  Cell 163(7): 1770--1782.
FlyBase ID
FBrf0230454
Publication Type
Research paper
Abstract

We have defined a network of interacting Drosophila cell surface proteins in which a 21-member IgSF subfamily, the Dprs, binds to a nine-member subfamily, the DIPs. The structural basis of the Dpr-DIP interaction code appears to be dictated by shape complementarity within the Dpr-DIP binding interface. Each of the six dpr and DIP genes examined here is expressed by a unique subset of larval and pupal neurons. In the neuromuscular system, interactions between Dpr11 and DIP-γ affect presynaptic terminal development, trophic factor responses, and neurotransmission. In the visual system, dpr11 is selectively expressed by R7 photoreceptors that use Rh4 opsin (yR7s). Their primary synaptic targets, Dm8 amacrine neurons, express DIP-γ. In dpr11 or DIP-γ mutants, yR7 terminals extend beyond their normal termination zones in layer M6 of the medulla. DIP-γ is also required for Dm8 survival or differentiation. Our findings suggest that Dpr-DIP interactions are important determinants of synaptic connectivity.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC4720259 (PMC) (EuropePMC)
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    Language of Publication
    English
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    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
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    Alleles (22)
    Gene Groups (2)
    Genes (35)
    Physical Interactions (117)
    Polypeptides (2)
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    Natural transposons (1)
    Insertions (11)
    Experimental Tools (1)
    Transgenic Constructs (8)
    Transcripts (7)