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Citation
Cohn, R., Morantte, I., Ruta, V. (2015). Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila.  Cell 163(7): 1742--1755.
FlyBase ID
FBrf0230456
Publication Type
Research paper
Abstract

Learned and adaptive behaviors rely on neural circuits that flexibly couple the same sensory input to alternative output pathways. Here, we show that the Drosophila mushroom body functions like a switchboard in which neuromodulation reroutes the same odor signal to different behavioral circuits, depending on the state and experience of the fly. Using functional synaptic imaging and electrophysiology, we reveal that dopaminergic inputs to the mushroom body modulate synaptic transmission with exquisite spatial specificity, allowing individual neurons to differentially convey olfactory signals to each of their postsynaptic targets. Moreover, we show that the dopaminergic neurons function as an interconnected network, encoding information about both an animal's external context and internal state to coordinate synaptic plasticity throughout the mushroom body. Our data suggest a general circuit mechanism for behavioral flexibility in which neuromodulatory networks act with synaptic precision to transform a single sensory input into different patterns of output activity. PAPERCLIP.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC4732734 (PMC) (EuropePMC)
Related Publication(s)
Note

Neural Plasticity: Dopamine Tunes the Mushroom Body Output Network.
Waddell, 2016, Curr. Biol. 26(3): R109--R112 [FBrf0230911]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Alleles (33)
    Genes (9)
    Natural transposons (2)
    Insertions (11)
    Experimental Tools (4)
    Transgenic Constructs (30)
    Transcripts (1)