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Citation
Enomoto, M., Vaughen, J., Igaki, T. (2015). Non-autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis.  Cancer Sci. 106(12): 1651--1658.
FlyBase ID
FBrf0230636
Publication Type
Review
Abstract
Tumor progression is classically viewed as the Darwinian evolution of subclones that sequentially acquire genetic mutations and autonomously overproliferate. However, growing evidence suggests that tumor microenvironment and subclone heterogeneity contribute to non-autonomous tumor progression. Recent Drosophila studies revealed a common mechanism by which clones of genetically altered cells trigger non-autonomous overgrowth. Such "oncogenic niche cells" (ONCs) do not overgrow but instead stimulate neighbor overgrowth and metastasis. Establishment of ONCs depends on competition and cooperation between heterogeneous cell populations. This review characterizes diverse ONCs identified in Drosophila and describes the genetic basis of non-autonomous tumor progression. Similar mechanisms may contribute to mammalian cancer progression and recurrence.
PubMed ID
PubMed Central ID
PMC4714670 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cancer Sci.
    Title
    Cancer Science
    Publication Year
    2003-
    ISBN/ISSN
    1347-9032 1349-7006
    Data From Reference
    Genes (20)