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Citation
Loncle, N., Agromayor, M., Martin-Serrano, J., Williams, D.W. (2015). An ESCRT module is required for neuron pruning.  Sci. Rep. 5(): 8461.
FlyBase ID
FBrf0230887
Publication Type
Research paper
Abstract
Neural circuits are refined by both functional and structural changes. Structural remodeling by large-scale pruning occurs where relatively long neuronal branches are cut away from their parent neuron and removed by local degeneration. Until now, the molecular mechanisms executing such branch severing events have remained poorly understood. Here, we reveal a role for the Endosomal Sorting Complex Required for Transport (ESCRT) machinery during neuronal remodeling. Our data show that a specific ESCRT pruning module, including members of the ESCRT-I and ESCRT-III complexes, but not ESCRT-0 or ESCRT-II, are required for the neurite scission event during pruning. Furthermore we show that this ESCRT module requires a direct, in vivo, interaction between Shrub/CHMP4B and the accessory protein Myopic/HD-PTP.
PubMed ID
PubMed Central ID
PMC4327575 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Sci. Rep.
    Title
    Scientific reports
    ISBN/ISSN
    2045-2322
    Data From Reference
    Alleles (40)
    Genes (20)
    Physical Interactions (1)
    Natural transposons (2)
    Insertions (10)
    Experimental Tools (1)
    Transgenic Constructs (25)