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Bosveld, F., Markova, O., Guirao, B., Martin, C., Wang, Z., Pierre, A., Balakireva, M., Gaugue, I., Ainslie, A., Christophorou, N., Lubensky, D.K., Minc, N., Bellaïche, Y. (2016). Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis.  Nature 530(7591): 495--498.
FlyBase ID
FBrf0231096
Publication Type
Research paper
Abstract

The orientation of cell division along the long axis of the interphase cell--the century-old Hertwig's rule--has profound roles in tissue proliferation, morphogenesis, architecture and mechanics. In epithelial tissues, the shape of the interphase cell is influenced by cell adhesion, mechanical stress, neighbour topology, and planar polarity pathways. At mitosis, epithelial cells usually adopt a rounded shape to ensure faithful chromosome segregation and to promote morphogenesis. The mechanisms underlying interphase cell shape sensing in tissues are therefore unknown. Here we show that in Drosophila epithelia, tricellular junctions (TCJs) localize force generators, pulling on astral microtubules and orienting cell division via the Dynein-associated protein Mud independently of the classical Pins/Gαi pathway. Moreover, as cells round up during mitosis, TCJs serve as spatial landmarks, encoding information about interphase cell shape anisotropy to orient division in the rounded mitotic cell. Finally, experimental and simulation data show that shape and mechanical strain sensing by the TCJs emerge from a general geometric property of TCJ distributions in epithelial tissues. Thus, in addition to their function as epithelial barrier structures, TCJs serve as polarity cues promoting geometry and mechanical sensing in epithelial tissues.

PubMed ID
PubMed Central ID
PMC5450930 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for mud[DeltaC] deletion.
Bosveld and Song, 2016.8.3, Location data for mud[DeltaC] deletion. [FBrf0233100]

Note

Memorizing Shape to Orient Cell Division.
Michel and Dahmann, 2016, Dev. Cell 36(6): 589--590 [FBrf0232962]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference