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Citation
Squarr, A.J., Brinkmann, K., Chen, B., Steinbacher, T., Ebnet, K., Rosen, M.K., Bogdan, S. (2016). Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation.  J. Cell Biol. 212(5): 591--603.
FlyBase ID
FBrf0231153
Publication Type
Research paper
Abstract

Directional cell movements during morphogenesis require the coordinated interplay between membrane receptors and the actin cytoskeleton. The WAVE regulatory complex (WRC) is a conserved actin regulator. Here, we found that the atypical cadherin Fat2 recruits the WRC to basal membranes of tricellular contacts where a new type of planar-polarized whip-like actin protrusion is formed. Loss of either Fat2 function or its interaction with the WRC disrupts tricellular protrusions and results in the formation of nonpolarized filopodia. We provide further evidence for a molecular network in which the receptor tyrosine phosphatase Dlar interacts with the WRC to couple the extracellular matrix, the membrane, and the actin cytoskeleton during egg elongation. Our data uncover a mechanism by which polarity information can be transduced from a membrane receptor to a key actin regulator to control collective follicle cell migration during egg elongation. 4D-live imaging of rotating MCF10A mammary acini further suggests an evolutionary conserved mechanism driving rotational motions in epithelial morphogenesis.

PubMed ID
PubMed Central ID
PMC4772498 (PMC) (EuropePMC)
Related Publication(s)
Note

Rotating for elongation: Fat2 whips for the race.
Stürner and Tavosanis, 2016, J. Cell Biol. 212(5): 487--489 [FBrf0231252]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Cell Biol.
    Title
    Journal of Cell Biology
    Publication Year
    1966-
    ISBN/ISSN
    0021-9525
    Data From Reference
    Alleles (19)
    Genes (9)
    Physical Interactions (3)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (12)