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Zanet, J., Chanut-Delalande, H., Plaza, S., Payre, F. (2016). Small Peptides as Newcomers in the Control of Drosophila Development.  Curr. Topics Dev. Biol. 117(): 199--219.
FlyBase ID
FBrf0231233
Publication Type
Review
Abstract

Throughout the last century, studies using the fruit fly have contributed to the discovery of many key genetic elements that control animal development. Recent work has shed light on an unexpectedly large number of RNAs that lack the classical hallmarks of protein-coding genes and are thus referred to as noncoding RNAs. However, there is mounting evidence that both mRNA and noncoding RNAs often contain small open reading frames (sORFs/smORFs), which can be translated into peptides. While genome-wide profiling supports a pervasive translation of these noncanonical sORF/smORF/SEP peptides, their functions remain poorly understood. Here, we review recent data obtained in Drosophila demonstrating the overlooked role of smORF peptides in the control of development and adult life. Focusing on a few smORF peptides whose functions have been elucidated recently, we discuss the importance of these newly identified regulatory molecules and how they act to regulate the building and function of the whole organism.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Topics Dev. Biol.
    Title
    Current Topics in Developmental Biology
    Publication Year
    1966-
    ISBN/ISSN
    0070-2153
    Data From Reference
    Genes (15)