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Citation
Chung, H.L., Augustine, G.J., Choi, K.W. (2016). Drosophila Schip1 Links Expanded and Tao-1 to Regulate Hippo Signaling.  Dev. Cell 36(5): 511--524.
FlyBase ID
FBrf0231239
Publication Type
Research paper
Abstract
Regulation of organ size is essential in animal development, and Hippo (Hpo) signaling is a major conserved mechanism for controlling organ growth. In Drosophila, Hpo and Warts kinases are core components of this pathway and function as tumor suppressors by inhibiting Yorkie (Yki). Expanded (Ex) is a regulator of the Hpo activity, but how they are linked is unknown. Here, we show that Schip1, a Drosophila homolog of the mammalian Schwannomin interacting protein 1 (SCHIP1), provides a link between Ex and Hpo. Ex is required for apical localization of Schip1 in imaginal discs. Schip1 is necessary for promoting membrane localization and phosphorylation of Hpo by recruiting the Hpo kinase Tao-1. Taking these findings together, we conclude that Schip1 directly links Ex to Hpo signaling by recruiting Tao-1. This study provides insights into the mechanism of Tao-1 regulation and a potential growth control function for SCHIP1 in mammals.
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PubMed Central ID
Related Publication(s)
Personal communication to FlyBase
Location data for Schip1[49] excision deletion.
Chung and Choi, 2016.6.24, Location data for Schip1[49] excision deletion. [FBrf0232739]
Note
Schip1, a new upstream regulator of Hippo signaling.
Chung and Choi, 2016, Cell Cycle 15(16): 2097--2098 [FBrf0233640]
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Aberrations (1)
    Alleles (18)
    Gene Groups (1)
    Genes (14)
    Physical Interactions (5)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (15)