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Citation
Lacin, H., Truman, J.W. (2016). Lineage mapping identifies molecular and architectural similarities between the larval and adult Drosophila central nervous system.  eLife 5(): e13399.
FlyBase ID
FBrf0231327
Publication Type
Research paper
Abstract
Neurogenesis in Drosophila occurs in two phases, embryonic and post-embryonic, in which the same set of neuroblasts give rise to the distinct larval and adult nervous systems, respectively. Here, we identified the embryonic neuroblast origin of the adult neuronal lineages in the ventral nervous system via lineage-specific GAL4 lines and molecular markers. Our lineage mapping revealed that neurons born late in the embryonic phase show axonal morphology and transcription factor profiles that are similar to the neurons born post-embryonically from the same neuroblast. Moreover, we identified three thorax-specific neuroblasts not previously characterized and show that HOX genes confine them to the thoracic segments. Two of these, NB2-3 and NB3-4, generate leg motor neurons. The other neuroblast is novel and appears to have arisen recently during insect evolution. Our findings provide a comprehensive view of neurogenesis and show how proliferation of individual neuroblasts is dictated by temporal and spatial cues.
PubMed ID
PubMed Central ID
PMC4805552 (PMC) (EuropePMC)
Related Publication(s)
Note
Neurogenesis reunited.
Landgraf, 2016, eLife 5: e14955 [FBrf0239626]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference
    Aberrations (2)
    Alleles (48)
    Genes (32)
    Sequence Features (1)
    Natural transposons (1)
    Insertions (5)
    Experimental Tools (2)
    Transgenic Constructs (42)
    Transcripts (35)