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Citation
Grill, B., Murphey, R.K., Borgen, M.A. (2016). The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration.  Neural Dev. 11(1): 8.
FlyBase ID
FBrf0231377
Publication Type
Review
Abstract

During development, a coordinated and integrated series of events must be accomplished in order to generate functional neural circuits. Axons must navigate toward target cells, build synaptic connections, and terminate outgrowth. The PHR proteins (consisting of mammalian Phr1/MYCBP2, Drosophila Highwire and C. elegans RPM-1) function in each of these events in development. Here, we review PHR function across species, as well as the myriad of signaling pathways PHR proteins regulate. These findings collectively suggest that the PHR proteins are intracellular signaling hubs, a concept we explore in depth. Consistent with prominent developmental functions, genetic links have begun to emerge between PHR signaling networks and neurodevelopmental disorders, such as autism, schizophrenia and intellectual disability. Finally, we discuss the recent and important finding that PHR proteins regulate axon degeneration, which has further heightened interest in this fascinating group of molecules.

PubMed ID
PubMed Central ID
PMC4806438 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neural Dev.
    Title
    Neural Development
    Publication Year
    2006-
    ISBN/ISSN
    1749-8104
    Data From Reference
    Genes (12)