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Citation
Summerville, J.B., Faust, J.F., Fan, E., Pendin, D., Daga, A., Formella, J., Stern, M., McNew, J.A. (2016). The effects of ER morphology on synaptic structure and function in Drosophila melanogaster.  J. Cell Sci. 129(8): 1635--1648.
FlyBase ID
FBrf0232027
Publication Type
Research paper
Abstract

Hereditary spastic paraplegia (HSP) is a set of genetic diseases caused by mutations in one of 72 genes that results in age-dependent corticospinal axon degeneration accompanied by spasticity and paralysis. Two genes implicated in HSPs encode proteins that regulate endoplasmic reticulum (ER) morphology. Atlastin 1 (ATL1, also known as SPG3A) encodes an ER membrane fusion GTPase and reticulon 2 (RTN2, also known as SPG12) helps shape ER tube formation. Here, we use a new fluorescent ER marker to show that the ER within wild-typeDrosophilamotor nerve terminals forms a network of tubules that is fragmented and made diffuse upon loss of the atlastin 1 orthologatlatlorRtnl1loss decreases evoked transmitter release and increases arborization. Similar to other HSP proteins, Atl inhibits bone morphogenetic protein (BMP) signaling, and loss ofatlcauses age-dependent locomotor deficits in adults. These results demonstrate a crucial role for ER in neuronal function, and identify mechanistic links between ER morphology, neuronal function, BMP signaling and adult behavior.

PubMed ID
PubMed Central ID
PMC4852773 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Cell Sci.
    Title
    Journal of Cell Science
    Publication Year
    1966-
    ISBN/ISSN
    0021-9533
    Data From Reference