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Citation
Meunier, S., Shvedunova, M., Van Nguyen, N., Avila, L., Vernos, I., Akhtar, A. (2015). An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis.  Nat. Commun. 6(): 7889.
FlyBase ID
FBrf0232251
Publication Type
Research paper
Abstract

The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis. As the cell enters mitosis, KANSL1 and KANSL3 undergo a marked relocalisation from the chromatin to the mitotic spindle. By stabilizing microtubule minus ends in a RanGTP-dependent manner, they are essential for spindle assembly and chromosome segregation. Moreover, we identify KANSL3 as a microtubule minus-end-binding protein, revealing a new class of mitosis-specific microtubule minus-end regulators. By adopting distinct functions in interphase and mitosis, KANSL proteins provide a link to coordinate the tasks of faithful expression and inheritance of the genome during different phases of the cell cycle.

PubMed ID
PubMed Central ID
PMC4918316 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Commun.
    Title
    Nature communications
    ISBN/ISSN
    2041-1723
    Data From Reference
    Genes (7)
    Physical Interactions (6)