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Citation
Yamamoto-Hino, M., Goto, S. (2016). Spätzle-Processing Enzyme-independent Activation of the Toll Pathway in Drosophila Innate Immunity.  Cell Struct. Funct. 41(1): 55--60.
FlyBase ID
FBrf0232295
Publication Type
Research paper
Abstract
The Toll pathway regulates innate immunity in insects and vertebrates. The Drosophila Toll receptor is activated by a processed form of a ligand, Spätzle. Spätzle-processing enzyme (SPE) is the only enzyme identified to date that functions in converting Spätzle to an active form during the immune response. In the present study, Toll activation induced by immune challenge was almost suppressed in spätzle mutant larvae and adults, whereas it was present in SPE mutant larvae challenged with Micrococcus luteus and adults challenged with Bacillus subtilis. Our data suggest that an unidentified protease besides SPE processes Spätzle under conditions of microbial challenge.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Struct. Funct.
    Title
    Cell Structure and Function
    Publication Year
    1975-
    ISBN/ISSN
    0386-7196
    Data From Reference
    Gene Groups (2)
    Genes (9)
    Cell Lines (1)