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Citation
Wang, L., Li, Y.M., Lei, L., Liu, Y., Wang, X., Ma, K.Y., Chen, Z.Y. (2015). Cranberry anthocyanin extract prolongs lifespan of fruit flies.  Exp. Gerontol. 69(): 189--195.
FlyBase ID
FBrf0232454
Publication Type
Research paper
Abstract

Cranberry is an excellent source of dietary antioxidants. The present study investigated the effect of cranberry anthocyanin (CrA) extract on the lifespan of fruit flies with focus on its interaction with aging-related genes including superoxide dismutase (SOD), catalase (CAT), methuselah (MTH), insulin receptor (InR), target of rapamycin (TOR), hemipterus (Hep), and phosphoenolpyruvate carboxykinase (PEPCK). Results showed that diet containing 20mg/mL CrA could significantly prolong the mean lifespan of fruit flies by 10% compared with the control diet. This was accompanied by up-regulation of SOD1 and down-regulation of MTH, InR, TOR and PEPCK. The stress resistance test demonstrated that CrA could reduce the mortality rate induced by H2O2 but not by paraquat. It was therefore concluded that the lifespan-prolonging activity of CrA was most likely mediated by modulating the genes of SOD1, MTH, InR, TOR and PEPCK.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Exp. Gerontol.
    Title
    Experimental Gerontology
    Publication Year
    1964-
    ISBN/ISSN
    0531-5565
    Data From Reference
    Genes (9)