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Reference
Citation
Weavers, H., Evans, I.R., Martin, P., Wood, W. (2016). Corpse Engulfment Generates a Molecular Memory that Primes the Macrophage Inflammatory Response.  Cell 165(7): 1658--1671.
FlyBase ID
FBrf0232642
Publication Type
Research paper
Abstract

Macrophages are multifunctional cells that perform diverse roles in health and disease. Emerging evidence has suggested that these innate immune cells might also be capable of developing immunological memory, a trait previously associated with the adaptive system alone. While recent studies have focused on the dramatic macrophage reprogramming that follows infection and protects against secondary microbial attack, can macrophages also develop memory in response to other cues? Here, we show that apoptotic corpse engulfment by Drosophila macrophages is an essential primer for their inflammatory response to tissue damage and infection in vivo. Priming is triggered via calcium-induced JNK signaling, which leads to upregulation of the damage receptor Draper, thus providing a molecular memory that allows the cell to rapidly respond to subsequent injury or infection. This remarkable plasticity and capacity for memory places macrophages as key therapeutic targets for treatment of inflammatory disorders.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC4912690 (PMC) (EuropePMC)
Related Publication(s)
Note

Innate Immune Memory: Activation of Macrophage Killing Ability by Developmental Duties.
Schneider and Tate, 2016, Curr. Biol. 26(12): R503--R505 [FBrf0232690]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (1)
    Alleles (10)
    Genes (8)
    Insertions (1)
    Transgenic Constructs (8)
    Transcripts (1)