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Citation
Veeman, M.T., McDonald, J.A. (2016). Dynamics of cell polarity in tissue morphogenesis: a comparative view from Drosophila and Ciona.  F1000Res. 5(F1000 Faculty Rev): 1084.
FlyBase ID
FBrf0232648
Publication Type
Review
Abstract

Tissues in developing embryos exhibit complex and dynamic rearrangements that shape forming organs, limbs, and body axes. Directed migration, mediolateral intercalation, lumen formation, and other rearrangements influence the topology and topography of developing tissues. These collective cell behaviors are distinct phenomena but all involve the fine-grained control of cell polarity. Here we review recent findings in the dynamics of polarized cell behavior in both the Drosophila ovarian border cells and the Ciona notochord. These studies reveal the remarkable reorganization of cell polarity during organ formation and underscore conserved mechanisms of developmental cell polarity including the Par/atypical protein kinase C (aPKC) and planar cell polarity pathways. These two very different model systems demonstrate important commonalities but also key differences in how cell polarity is controlled in tissue morphogenesis. Together, these systems raise important, broader questions on how the developmental control of cell polarity contributes to morphogenesis of diverse tissues across the metazoa.

PubMed ID
PubMed Central ID
PMC4892338 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    F1000Res.
    Title
    F1000Research
    ISBN/ISSN
    2046-1402
    Data From Reference
    Genes (11)