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Citation
Fischer, P., Preiss, A., Nagel, A.C. (2016). A triangular connection between Cyclin G, PP2A and Akt1 in the regulation of growth and metabolism in Drosophila.  Fly 10(1): 11--18.
FlyBase ID
FBrf0232706
Publication Type
Research paper
Abstract

Size and weight control is a tightly regulated process, involving the highly conserved Insulin receptor/target of rapamycin (InR/TOR) signaling cascade. We recently identified Cyclin G (CycG) as an important modulator of InR/TOR signaling activity in Drosophila. cycG mutant flies are underweight and show a disturbed fat metabolism resembling TOR mutants. In fact, InR/TOR signaling activity is disturbed in cycG mutants at the level of Akt1, the central kinase linking InR and TORC1. Akt1 is negatively regulated by protein phosphatase PP2A. Notably the binding of the PP2A B'-regulatory subunit Widerborst (Wdb) to Akt1 is differentially regulated in cycG mutants, presumably by a direct interaction of CycG and Wdb. Since the metabolic defects of cycG mutant animals are abrogated by a concomitant loss of Wdb, CycG presumably influences Akt1 activity at the PP2A nexus. Here we show that Well rounded (Wrd), another B' subunit of PP2A in Drosophila, binds CycG similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG mutants. We propose a model, whereby the binding of CycG to a particular B'-regulatory subunit influences the tissue specific activity of PP2A, required for the fine tuning of the InR/TOR signaling cascade in Drosophila.

PubMed ID
PubMed Central ID
PMC4934794 (PMC) (EuropePMC)
Related Publication(s)
Research paper

Cyclin G Functions as a Positive Regulator of Growth and Metabolism in Drosophila.
Fischer et al., 2015, PLoS Genet. 11(8): e1005440 [FBrf0229285]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Fly
    Title
    Fly
    Publication Year
    2007-
    ISBN/ISSN
    1933-6934 1933-6942
    Data From Reference
    Alleles (4)
    Gene Groups (4)
    Genes (7)
    Physical Interactions (6)
    Cell Lines (1)