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Citation
Norman, M., Vuilleumier, R., Springhorn, A., Gawlik, J., Pyrowolakis, G. (2016). Pentagone internalises glypicans to fine-tune multiple signalling pathways.  eLife 5(): e13301.
FlyBase ID
FBrf0232782
Publication Type
Research paper
Abstract

Tight regulation of signalling activity is crucial for proper tissue patterning and growth. Here we investigate the function of Pentagone (Pent), a secreted protein that acts in a regulatory feedback during establishment and maintenance of BMP/Dpp morphogen signalling during Drosophila wing development. We show that Pent internalises the Dpp co-receptors, the glypicans Dally and Dally-like protein (Dlp), and propose that this internalisation is important in the establishment of a long range Dpp gradient. Pent-induced endocytosis and degradation of glypicans requires dynamin- and Rab5, but not clathrin or active BMP signalling. Thus, Pent modifies the ability of cells to trap and transduce BMP by fine-tuning the levels of the BMP reception system at the plasma membrane. In addition, and in accordance with the role of glypicans in multiple signalling pathways, we establish a requirement of Pent for Wg signalling. Our data propose a novel mechanism by which morphogen signalling is regulated.

PubMed ID
PubMed Central ID
PMC4924993 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference
    Aberrations (2)
    Alleles (44)
    Genes (19)
    Natural transposons (1)
    Insertions (7)
    Experimental Tools (7)
    Transgenic Constructs (30)