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Citation
Jana, S.C., Bettencourt-Dias, M., Durand, B., Megraw, T.L. (2016). Drosophila melanogaster as a model for basal body research.  Cilia 5(): 22.
FlyBase ID
FBrf0232797
Publication Type
Review
Abstract

The fruit fly, Drosophila melanogaster, is one of the most extensively studied organisms in biological research and has centrioles/basal bodies and cilia that can be modelled to investigate their functions in animals generally. Centrioles are nine-fold symmetrical microtubule-based cylindrical structures required to form centrosomes and also to nucleate the formation of cilia and flagella. When they function to template cilia, centrioles transition into basal bodies. The fruit fly has various types of basal bodies and cilia, which are needed for sensory neuron and sperm function. Genetics, cell biology and behaviour studies in the fruit fly have unveiled new basal body components and revealed different modes of assembly and functions of basal bodies that are conserved in many other organisms, including human, green algae and plasmodium. Here we describe the various basal bodies of Drosophila, what is known about their composition, structure and function.

PubMed ID
PubMed Central ID
PMC4932733 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cilia
    Title
    Cilia
    ISBN/ISSN
    2046-2530
    Data From Reference