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Citation
Yuan, K., Seller, C.A., Shermoen, A.W., O'Farrell, P.H. (2016). Timing the Drosophila Mid-Blastula Transition: A Cell Cycle-Centered View.  Trends Genet. 32(8): 496--507.
FlyBase ID
FBrf0232936
Publication Type
Review
Abstract

At the mid-blastula transition (MBT), externally developing embryos refocus from increasing cell number to elaboration of the body plan. Studies in Drosophila reveal a sequence of changes in regulators of Cyclin:Cdk1 that increasingly restricts the activity of this cell cycle kinase to slow cell cycles during early embryogenesis. By reviewing these events, we provide an outline of the mechanisms slowing the cell cycle at and around the time of MBT. The perspectives developed should provide a guiding paradigm for the study of other MBT changes as the embryo transits from maternal control to a regulatory program centered on the expression of zygotic genes.

PubMed ID
PubMed Central ID
PMC4958567 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Trends Genet.
    Title
    Trends in Genetics
    Publication Year
    1985-
    ISBN/ISSN
    0168-9525
    Data From Reference
    Genes (7)