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Citation
Hu, L., Xu, J., Yin, M.X., Zhang, L., Lu, Y., Wu, W., Xue, Z., Ho, M.S., Gao, G., Zhao, Y., Zhang, L. (2016). Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded.  Cell Discov. 2(): 15047.
FlyBase ID
FBrf0232944
Publication Type
Research paper
Abstract

Non-receptor tyrosine kinase activated cdc42 kinase was reported to participate in several types of cancers in mammals. It is also believed to have an anti-apoptotic function in Drosophila. Here, we report the identification of Drosophila activated cdc42 kinase as a growth promoter and a novel Hippo signaling pathway regulator. We find that activated cdc42 kinase promotes tissue growth through modulating Yorkie activity. Furthermore, we demonstrate that activated cdc42 kinase interacts with Expanded and induces tyrosine phosphorylation of Expanded on multiple sites. We propose a model that activated cdc42 kinase negatively regulates Expanded by changing its phosphorylation status to promote tissue growth. Moreover, we show that ack genetically interacts with merlin and expanded. Thus, we identify Drosophila activated cdc42 kinase as a Hippo pathway regulator.

PubMed ID
PubMed Central ID
PMC4860957 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell Discov.
    Title
    Cell discovery
    ISBN/ISSN
    2056-5968
    Data From Reference