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Citation
Li, M., Lindblad, J.L., Perez, E., Bergmann, A., Fan, Y. (2016). Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation.  BMC Biol. 14(): 70.
FlyBase ID
FBrf0233174
Publication Type
Research paper
Abstract
ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent process which is involved in tissue repair and regeneration after massive stress-induced apoptotic cell loss. Under certain conditions, AiP can cause tissue overgrowth with implications for cancer. Here, we show that Atg1 in Drosophila (dAtg1) has a previously unrecognized function for both regenerative and overgrowth-promoting AiP in eye and wing imaginal discs. dAtg1 acts genetically downstream of and is transcriptionally induced by JNK activity, and it is required for JNK-dependent production of mitogens such as Wingless for AiP. Interestingly, this function of dAtg1 in AiP is independent of its roles in autophagy and in neuronal development. In addition to a role of dAtg1 in autophagy and neuronal development, we report a third function of dAtg1 for AiP.
PubMed ID
PubMed Central ID
PMC4992243 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    BMC Biol.
    Title
    BMC Biology
    ISBN/ISSN
    1741-7007
    Data From Reference