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Yadav, A.K., Srikrishna, S., Gupta, S.C. (2016). Cancer Drug Development Using Drosophila as an in vivo Tool: From Bedside to Bench and Back.  Trends Pharmacol. Sci. 37(9): 789--806.
FlyBase ID
FBrf0233229
Publication Type
Review
Abstract

The fruit fly Drosophila melanogaster has been used for modeling cancer and as an in vivo tool for the validation and/or development of cancer therapeutics. The impetus for the use of Drosophila in cancer research stems from the high conservation of its signaling pathways, lower genetic redundancy, short life cycle, genetic amenability, and ease of maintenance. Several cell signaling pathways in Drosophila have been used for cancer drug development. The efficacy of combination therapy and uptake/bioavailability of drugs have also been studied. Drosophila has been validated using several FDA-approved drugs, suggesting a potential application of this model in drug repurposing. The model is emerging as a powerful tool for high-throughput screening and should significantly reduce the cost and time associated with drug development. In this review we discuss the applications of Drosophila in cancer drug development. The advantages and limitations of the model are discussed.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Trends Pharmacol. Sci.
    Title
    Trends in Pharmacological Sciences
    Publication Year
    1979-
    ISBN/ISSN
    0165-6147
    Data From Reference