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Maistrenko, O.M., Serga, S.V., Vaiserman, A.M., Kozeretska, I.A. (2016). Longevity-modulating effects of symbiosis: insights from Drosophila-Wolbachia interaction.  Biogerontology 17(5-6): 785--803.
FlyBase ID
FBrf0233700
Publication Type
Review
Abstract

Microbial communities are known to significantly affect various fitness components and survival of their insect hosts, including Drosophila. The composition of symbiotic microbiota has been shown to change with the host's aging. It is unclear whether these changes are caused by the aging process or, vice versa, they affect the host's aging and longevity. Recent findings indicate that fitness and lifespan of Drosophila are affected by endosymbiotic bacteria Wolbachia. These effects, however, are inconsistent and have been reported both to extend and shorten longevity. The main molecular pathways underlying the lifespan-modulating effects of Wolbachia remain unclear, however insulin/insulin-like growth factor, immune deficiency, ecdysteroid synthesis and signaling and c-Jun N-terminal kinase pathways as well as heat shock protein synthesis and autophagy have been proposed to play a role. Here we revise the current evidence that elucidates the impact of Wolbachia endosymbionts on the aging processes in Drosophila.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biogerontology
    Title
    Biogerontology
    Publication Year
    2000-
    ISBN/ISSN
    1389-5729
    Data From Reference