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Citation
Catrina, I.E., Bayer, L.V., Yanez, G., McLaughlin, J.M., Malaczek, K., Bagaeva, E., Marras, S.A., Bratu, D.P. (2016). The temporally controlled expression of Drongo, the fruit fly homolog of AGFG1, is achieved in female germline cells via P-bodies and its localization requires functional Rab11.  RNA Biol. 13(11): 1117--1132.
FlyBase ID
FBrf0233867
Publication Type
Research paper
Abstract

To achieve proper RNA transport and localization, RNA viruses exploit cellular vesicular trafficking pathways. AGFG1, a host protein essential for HIV-1 and Influenza A replication, has been shown to mediate release of intron-containing viral RNAs from the perinuclear region. It is still unknown what its precise role in this release is, or whether AGFG1 also participates in cytoplasmic transport. We report for the first time the expression patterns during oogenesis for Drongo, the fruit fly homolog of AGFG1. We find that temporally controlled Drongo expression is achieved by translational repression of drongo mRNA within P-bodies. Here we show a first link between the recycling endosome pathway and Drongo, and find that proper Drongo localization at the oocyte's cortex during mid-oogenesis requires functional Rab11.

PubMed ID
PubMed Central ID
PMC5100350 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    RNA Biol.
    Title
    RNA Biology.
    Publication Year
    2004-
    ISBN/ISSN
    1547-6286 1555-8584
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