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Citation
Richards, C.D., Burke, R. (2016). A fly's eye view of zinc homeostasis: Novel insights into the genetic control of zinc metabolism from Drosophila.  Arch. Biochem. Biophys. 611(): 142--149.
FlyBase ID
FBrf0233928
Publication Type
Review
Abstract

The core zinc transport machinery is well conserved between invertebrates and mammals, with the vinegar fly Drosophila melanogaster having clear homologues of all major groups of mammalian ZIP and ZNT transport genes. Functional characterization of several of the fly genes has revealed functional conservation between related fly and mammalian zinc transporters in some but not all cases, indicating that Drosophila is a useful model for examining mammalian zinc metabolism. Furthermore, Drosophila research, sometimes quite serendipitously, has provided novel insights into the function of zinc transporters and into zinc-related pathologies, which are highlighted here. Finally, the future research potential of the fly in nutrient metabolism is explored, with reference to emerging experimental technologies.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Arch. Biochem. Biophys.
    Title
    Archives of Biochemistry and Biophysics
    Publication Year
    1951-
    ISBN/ISSN
    0003-9861
    Data From Reference