Open Close
Reference
Citation
Kucherenko, M.M., Ilangovan, V., Herzig, B., Shcherbata, H.R., Bringmann, H. (2016). TfAP-2 is required for night sleep in Drosophila.  BMC Neurosci. 17(1): 72.
FlyBase ID
FBrf0233930
Publication Type
Research paper
Abstract

The AP-2 transcription factor APTF-1 is crucially required for developmentally controlled sleep behavior in Caenorhabditis elegans larvae. Its human ortholog, TFAP-2beta, causes Char disease and has also been linked to sleep disorders. These data suggest that AP-2 transcription factors may be highly conserved regulators of various types of sleep behavior. Here, we tested the idea that AP-2 controls adult sleep in Drosophila. Drosophila has one AP-2 ortholog called TfAP-2, which is essential for viability. To investigate its potential role in sleep behavior and neural development, we specifically downregulated TfAP-2 in the nervous system. We found that neuronal TfAP-2 knockdown almost completely abolished night sleep but did not affect day sleep. TfAP-2 insufficiency affected nervous system development. Conditional TfAP-2 knockdown in the adult also produced a modest sleep phenotype, suggesting that TfAP-2 acts both in larval as well as in differentiated neurons. Thus, our results show that AP-2 transcription factors are highly conserved regulators of development and sleep.

PubMed ID
PubMed Central ID
PMC5103423 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    BMC Neurosci.
    Title
    BMC Neuroscience
    Publication Year
    2000-
    ISBN/ISSN
    1471-2202
    Data From Reference