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Citation
Brill, J.A., Yildirim, S., Fabian, L. (2016). Phosphoinositide signaling in sperm development.  Semin. Cell Dev. Biol. 59(): 2--9.
FlyBase ID
FBrf0234077
Publication Type
Review
Abstract

Phosphatidylinositol phosphates (PIPs)(1) are membrane lipids with crucial roles during cell morphogenesis, including the establishment of cytoskeletal organization, membrane trafficking, cell polarity, cell-cycle control and signaling. Recent studies in mice (Mus musculus), fruit flies (Drosophila melanogaster) and other organisms have defined germ cell intrinsic requirements for these lipids and their regulatory enzymes in multiple aspects of sperm development. In particular, PIP levels are crucial in germline stem cell maintenance, spermatogonial proliferation and survival, spermatocyte cytokinesis, spermatid polarization, sperm tail formation, nuclear shaping, and production of mature, motile sperm. Here, we briefly review the stages of spermatogenesis and discuss the roles of PIPs and their regulatory enzymes in male germ cell development.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Semin. Cell Dev. Biol.
    Title
    Seminars in cell and developmental biology
    Publication Year
    1996-
    ISBN/ISSN
    1084-9521
    Data From Reference
    Genes (8)