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Yun, X., Huang, Q., Rao, W., Xiao, C., Zhang, T., Mao, Z., Wan, Z. (2017). A comparative assessment of cytotoxicity of commonly used agricultural insecticides to human and insect cells.  Ecotoxicol. Environ. Saf. 137(): 179--185.
FlyBase ID
FBrf0234347
Publication Type
Research paper
Abstract
The cytotoxic potential of 13 commonly used agricultural insecticides was examined using cell-based systems with three human HepG2, Hek293, HeLa cells and three insect Tn5B1-4, Sf-21, and Drosophila S2 cells. Data showed that (1) an enhancement of some insecticides (e.g. pyrethroids) on cells proliferation; (2) an inhibition of some insecticides on cells viability; (3) various levels of susceptibility of different cells to the same insecticide; and (4) the cell type dependent sensitivity to different insecticides. The degree of cytotoxicity of insecticides on human cells was significantly lower than that on insect cells (P<0.05). Methomyl, even 20μg/ml, showed little cytotoxicity at 24h exposure whereas emamectin benzoate possessed the strongest cytotoxic potential in a dose-dependent fashion. The results revealed comparable cytotoxic property of agricultural insecticides against intact cells.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Ecotoxicol. Environ. Saf.
    Title
    Ecotoxicology and Environmental Safety
    Publication Year
    1977-
    ISBN/ISSN
    0147-6513
    Data From Reference
    Cell Lines (1)