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Citation
Liu, D., Shaukat, Z., Xu, T., Denton, D., Saint, R., Gregory, S. (2016). Autophagy regulates the survival of cells with chromosomal instability.  Oncotarget 7(39): 63913--63923.
FlyBase ID
FBrf0234422
Publication Type
Research paper
Abstract

Chromosomal instability (CIN) refers to genomic instability in which cells have gained or lost chromosomes or chromosomal fragments. A high level of CIN is common in solid tumours and is associated with cancer drug resistance and poor prognosis. The impact of CIN-induced stress and the resulting cellular responses are only just beginning to emerge. Using proliferating tissue in Drosophila as a model, we found that autophagy is activated in CIN cells and is necessary for their survival. Specifically, increasing the removal of defective mitochondria by mitophagy is able to lower levels of reactive oxygen species and the resultant cellular damage that is normally seen in CIN cells. In response to DNA damage, CIN is increased in a positive feedback loop, and we found that increasing autophagy by Tor depletion could decrease the level of CIN in proliferating cells. These findings underline the importance of autophagy control in the development of CIN tumours.

PubMed ID
PubMed Central ID
PMC5325413 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Oncotarget
    Title
    Oncotarget
    ISBN/ISSN
    1949-2553
    Data From Reference