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Citation
Rathore, O.S., Faustino, A., Prudêncio, P., Van Damme, P., Cox, C.J., Martinho, R.G. (2016). Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms.  Sci. Rep. 6(): 21304.
FlyBase ID
FBrf0234437
Publication Type
Research paper
Abstract

Protein N-terminal acetylation is an ancient and ubiquitous co-translational modification catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). Prokaryotes have at least 3 NATs, whereas humans have six distinct but highly conserved NATs, suggesting an increase in regulatory complexity of this modification during eukaryotic evolution. Despite this, and against our initial expectations, we determined that NAT diversification did not occur in the eukaryotes, as all six major human NATs were most likely present in the Last Eukaryotic Common Ancestor (LECA). Furthermore, we also observed that some NATs were actually secondarily lost during evolution of major eukaryotic lineages; therefore, the increased complexity of the higher eukaryotic proteome occurred without a concomitant diversification of NAT complexes.

PubMed ID
PubMed Central ID
PMC4748286 (PMC) (EuropePMC)
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    Language of Publication
    English
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    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Sci. Rep.
    Title
    Scientific reports
    ISBN/ISSN
    2045-2322
    Data From Reference
    Alleles (2)
    Gene Groups (5)
    Genes (30)
    Physical Interactions (4)
    Natural transposons (1)
    Experimental Tools (2)
    Transgenic Constructs (1)