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Citation
Blumenstiel, J.P., Erwin, A.A., Hemmer, L.W. (2016). What Drives Positive Selection in the Drosophila piRNA Machinery? The Genomic Autoimmunity Hypothesis.  Yale J. Biol. Med. 89(4): 499--512.
FlyBase ID
FBrf0234447
Publication Type
Review
Abstract

In animals, PIWI-interacting RNAs (piRNAs) play a crucial role in genome defense. Moreover, because piRNAs can be maternally transmitted, they contribute to the epigenetic profile of inheritance. Multiple studies, especially in Drosophila, have demonstrated that the machinery of piRNA biogenesis is often the target of positive selection. Because transposable elements (TEs) are a form of genetic parasite, positive selection in the piRNA machinery is often explained by analogy to the signatures of positive selection commonly observed in genes that play a role in host-parasite dynamics. However, the precise mechanisms that drive positive selection in the piRNA machinery are not known. In this review, we outline several mechanistic models that might explain pervasive positive selection in the piRNA machinery of Drosophila species. We propose that recurrent positive selection in the piRNA machinery can be partly explained by an ongoing tension between selection for sensitivity required by genome defense and selection for specificity to avoid the off-target effects of maladaptive genic silencing by piRNA.

PubMed ID
PubMed Central ID
PMC5168828 (PMC) (EuropePMC)
DOI
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Yale J. Biol. Med.
    Title
    Yale Journal of Biology and Medicine
    Publication Year
    1928-
    ISBN/ISSN
    0044-0086
    Data From Reference