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VanKirk, T., Powers, E., Dowse, H.B. (2017). Melatonin increases the regularity of cardiac rhythmicity in the Drosophila heart in both wild-type and strains bearing pathogenic mutations.  J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. 187(1): 63--78.
FlyBase ID
FBrf0234492
Publication Type
Research paper
Abstract

Melatonin is a hormone that is critical for normal circadian and seasonal rhythmicity in a wide range of different animals. It is a powerful antioxidant commonly used to prevent reperfusion injury to the heart after infarction. We show here it has other more far-reaching effects on cardiac function. Using the Drosophila model, we show that injection of melatonin increases the regularity of heartbeat significantly and can rescue rhythmicity in flies bearing mutations that adversely affect cardiac function. Notably, melatonin increases cardiac regularity independent of alteration of heart rate. We provide compelling evidence that melatonin's action as an antioxidant is not the mechanism underlying improved cardiac performance. We have strong evidence that melatonin's action on the heart is mediated via a specific G-Protein-coupled receptor encoded by the CG 4313 gene that our results implicate as a candidate melatonin receptor. These results open a line of questioning about fundamental aspects of cardiac pacemaking.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol.
    Title
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
    Publication Year
    1984-
    ISBN/ISSN
    0174-1578 1432-136X
    Data From Reference
    Aberrations (1)
    Alleles (11)
    Genes (10)
    Transgenic Constructs (6)