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Xu, J., Hao, X., Yin, M.X., Lu, Y., Jin, Y., Xu, J., Ge, L., Wu, W., Ho, M., Yang, Y., Zhao, Y., Zhang, L. (2017). Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity.  Development 144(8): 1510--1517.
FlyBase ID
FBrf0235264
Publication Type
Research paper
Abstract

The Drosophila larval central nervous system comprises the central brain, ventral nerve cord and optic lobe. In these regions, neuroblasts (NBs) divide asymmetrically to self-renew and generate differentiated neurons or glia. To date, mechanisms of preventing neuron dedifferentiation are still unclear, especially in the optic lobe. Here, we show that the zinc-finger transcription factor Nerfin-1 is expressed in early-stage medulla neurons and is essential for maintaining their differentiation. Loss of Nerfin-1 activates Notch signaling, which promotes neuron-to-NB reversion. Repressing Notch signaling largely rescues dedifferentiation in nerfin-1 mutant clones. Thus, we conclude that Nerfin-1 represses Notch activity in medulla neurons and prevents them from dedifferentiation.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference