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Citation
Erceg, J., Pakozdi, T., Marco-Ferreres, R., Ghavi-Helm, Y., Girardot, C., Bracken, A.P., Furlong, E.E. (2017). Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements.  Genes Dev. 31(6): 590--602.
FlyBase ID
FBrf0235279
Publication Type
Research paper
Abstract

Developmental gene expression is tightly regulated through enhancer elements, which initiate dynamic spatio-temporal expression, and Polycomb response elements (PREs), which maintain stable gene silencing. These two cis-regulatory functions are thought to operate through distinct dedicated elements. By examining the occupancy of the Drosophila pleiohomeotic repressive complex (PhoRC) during embryogenesis, we revealed extensive co-occupancy at developmental enhancers. Using an established in vivo assay for PRE activity, we demonstrated that a subset of characterized developmental enhancers can function as PREs, silencing transcription in a Polycomb-dependent manner. Conversely, some classic Drosophila PREs can function as developmental enhancers in vivo, activating spatio-temporal expression. This study therefore uncovers elements with dual function: activating transcription in some cells (enhancers) while stably maintaining transcriptional silencing in others (PREs). Given that enhancers initiate spatio-temporal gene expression, reuse of the same elements by the Polycomb group (PcG) system may help fine-tune gene expression and ensure the timely maintenance of cell identities.

PubMed ID
PubMed Central ID
PMC5393054 (PMC) (EuropePMC)
Related Publication(s)
Note

Multitasking by Polycomb response elements.
Jaensch et al., 2017, Genes Dev. 31(11): 1069--1072 [FBrf0237017]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference